The immune system tracks pathogen invasion and cell death and responds to danger.
Defects in the immune system, such as lack of response, overreaction to signals, or incorrect recognition of antigen as self or foreign, can cause human diseases including cancer, autoimmunity and uncontrolled pathogen infection.
We explore the interactions between immune cells and cancer and search for new targets for immunotherapy. In addition, we model the responses of innate immune cells to pathogens. To investigate these complex interactions, we use state of the art genomic and genetic technologies.
We investigate the effect of NF1 deficiency, aiming to reverse the phenotypes of mutations in NF1 gene.